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Cardioselective beta blockers asthma

Respiratory effect of beta-blockers in people with asthma

Cardioselective beta-blockers prescribed to people with asthma and CVD were not associated with a significantly increased risk of moderate or severe asthma exacerbations and potentially could be used more widely when strongly indicated Introduction Beta-blockers are key in the management of cardiovascular diseases but blocking airway β 2 -receptors can cause severe and sometimes fatal bronchoconstriction in people with asthma. Although cardioselective β 1 -blockers may be safer than non-selective β-blockers, they remain relatively contraindicated and under-prescribed Cardioselective beta blockers This type of medicine was specifically designed to block the beta receptors only in heart cells. Therefore, they are generally considered to be safe for people with asthma and other lung conditions. 3 Examples include Evidence from clinical trials suggests that cardioselective beta-blockers are reasonably well tolerated in asthma with meta-analyses suggesting that adverse respiratory response to beta-blockers varies according to the degree of cardioselectivity, dose of administration and individual response [6, 7]

Video: The safety of cardioselective β1-blockers in asthma

Beta Blockers: Are They Safe to Use If You Have Asthma

  1. Cardioselective β-Blockers Generally Are Safe in Asthma Patients David J. Amrol, MD, reviewing Morales DR et al. Chest 2014 Apr However, patients should still be warned about possible early asthma worsening. β-blockers can cause airway obstruction and even severe exacerbations in asthma patients
  2. Beta Blockers in COPD or Asthma. Many patients with obstructive lung diseases have concomitant conditions such as hypertension, coronary artery disease, or congestive heart failure that.
  3. As for asthma, chronic use of cardioselective beta blockers doesn't seem to precipitate asthma attacks in mild or moderate asthma. A 2002 meta-analysis in Annals Internal Medicine showed that a single dose of beta blocker did reduce asthmatics' FEV1 by ~7.5% predicted, but this decrement went away with chronic use

Cardioselective β-Blockers Generally Are Safe in Asthma

  1. Cite this: Cardioselective Beta Blocker Use in Patients With Asthma and Chronic Obstructive Pulmonary Disease: An Evidence-Based Approach to Standards of Care - Medscape - Nov 01, 2003. References.
  2. Of 54,962 patients without contraindications to beta-blockers, patients with COPD or asthma (20%) were significantly less likely to be prescribed beta-blockers at discharge after AMI. Patients with COPD or asthma who were not on beta-agonist had lower one-year mortality if they were on BBs
  3. Beta blockers are widely used in the management of cardiac conditions and thyrotoxicosis, and to reduce perioperative complications. Asthma and chronic obstructive pulmonary disease (COPD) have.
  4. symptoms of asthma over time lead - ing to low-grade morbidity and reduction in quality of life. The BNF advises that beta-blockers should be avoided in patients with a history of asthma or bronchospasm. There are a number of case reports of beta-blockers causing bronchoconstriction in patients with a past history of severe COPD.
  5. Asthma — In patients with asthma, beta blockers can cause increased bronchial obstruction and airway reactivity, as well as resistance to the effects of inhaled or oral beta receptor agonists (such as albuterol or terbutaline) [ 5-7 ]
  6. In asthmatics, cardioselective beta-blockers had the following effects: Reduced FEV1 (mean drop 7%, although 1 in 8 had a drop of 20% or more). Reduced response to beta-agonists by an average of 10% (suggesting it would be harder to treat an asthma attack). 1 in 33 had worsening of their asthma
  7. Use cardioselective beta-blockers in case of chronic obstructive pulmonary disease (COPD); start low and go slow. Asthma is a relative contraindication for the use of beta-blockers. These drugs should be used with caution and preferably with specialist advice. Types and typical dosages of the most frequently used beta-blockers

Cardioselective Beta Blocker Use in Patients With Asthm

  1. If a beta-blocker must be used in a patient with asthma, cardioselective beta-blockers, e.g. bisoprolol and metoprolol, are better tolerated than non-selective beta-blockers, although they are still associated with a decrease in lung function and adverse effects. 2
  2. The benefits of cardioselective beta-blocker therapy outweigh the associated risks in patients with nonsevere asthma after myocardial infarction (MI) or for the long-term treatment of heart failure. 1-5 We have recently observed both medical residents and attending physicians prescribing noncardioselective beta-blockers to patients with asthma (Table)
  3. model of asthma in mice ( 3 ). In previous studies, these authors demonstrated that in contrast to the acute effects of beta-blockers on airway.
  4. Cardioselective beta-blockers given in mild to moderate reversible airway disease or COPD do not produce adverse respiratory effects. Given their demonstrated benefit in conditions such as heart failure, cardiac arrhythmias and hypertension, these agents should not be withheld from such patients. Long-term safety still needs to be established
  5. Beta blockers are a group of drugs that inhibit the sympathetic activation of β-adrenergic receptors. Cardioselective blockers (e.g., atenolol, bisoprolol) primarily block β1 receptors in the hea..

Asthma. The 2007 National Heart, Lung, and Blood Institute (NHLBI) asthma guidelines recommend against the use of non-selective beta blockers in asthmatics, while allowing for the use of cardioselective beta blockers Many of us were taught to avoid beta-blockers in these patients...because of concerns about bronchoconstriction. But cardioSELECTIVE options (metoprolol, bisoprolol, etc) don't cause more exacerbations or reduce airway function in COPD or asthma. And patients still respond to beta-agonists (albuterol, salmeterol, etc)

Cardioselective Beta Blocker Use in Patients With Asthma

Beta blockers safe for most patients with asthma or COPD

  1. Beta-blockers are also useful in the management of supraventricular tachycardias, and are used to control those following myocardial infarction. Esmolol hydrochloride is a relatively cardioselective beta-blocker with a very short duration of action, used intravenously for the short-term treatment of supraventricular arrhythmias, sinus.
  2. Beta-blockers are key in the management of cardiovascular diseases but blocking airway β 2 -receptors can cause severe and sometimes fatal bronchoconstriction in people with asthma. Although cardioselective β 1 -blockers may be safer than non-selective β-blockers, they remain relatively contraindicated and under-prescribed
  3. Moreover, there is another controversy emerging for beta-blockers—the paradoxical hypothesis that beta-blockers might actually be beneficial in asthma is now being tested in clinical trials . These studies were initiated after long-term exposure was shown to reduce lung sensitivity in a mouse model of asthma
  4. 1 Santa Fe, NM 87505, USA. npdevitt@gmail.com. I am surprised by a journal such as The BMJ, which promotes evidence based medicine, repeating the urban myth that β blockers are not safe in patients with asthma. 1 Cardioselective β blockers certainly are safe to use in asthma. Recent evidence suggests that even older drug such as propranolol.
  5. In a single-blind, randomised, crossover study in 10 asthmatic patients, the effects of approximately equipotent oral doses of 3 cardioselective beta-blockers-atenolol (100 mg), metoprolol (100 mg), and acebutolol (300 mg)-and 4 non-cardioselective beta-blockers-proranolol (100 mg), oxprenolol (100 mg), pindolol (5 mg), and timolol (10 mg) upon FEV1 were compared. All drugs, except pindolol.

Medications That Trigger Asthma: Aspirin, ACE Inhibitors

(If a non-cardioselective beta blocker (e.g., carvedilol)), prescribed to patients with significant asthma or bronchostrinction, especially if with a positive methacholine challenge. *Both the immediate-release and extended-release carvedilol may be prescribed for heart failure Beta-blockers have been associated with an increase in bronchoconstriction and a decline in pulmonary function; however, their effect on signs and symptoms may not be as significant. 14,15 The greatest decline in lung function is associated with nonselective beta-blockers and is dose-dependent. 15 In the presence of asthma, cardioselective beta. (2003). Cardioselective Beta‐Blockers in Patients with Asthma and Concomitant Heart Failure or History of Myocardial Infarction: When Do Benefits Outweigh Risks? Journal of Asthma: Vol. 40, No. 8, pp. 839-845

The problem is that non-cardioselective beta blockers, those that block beta-1 and beta-2 receptors, may hurt people with asthma. This is because by blocking the beta-2 receptors, these. Non-cardioselective beta blockers, like propranolol or nadolol, helps minimize arrhythmias, blood pressure, heart rate, and the workload on the heart. But they also constrict the airways and may.

Anti-asthma drugs + Beta blockers - Drug Interactions. Non-cardioselective beta blockers (e.g. propranolol,timolol)should not be used in asthmatic subjects because they may causeserious bronchoconstriction, even if given as eye drops. Non-cardioselective beta blockers oppose bronchodilator effects ofbeta-agonist bronchodilators, and higher. However, non-cardioselective beta blockers can cause significant bronchial constriction and could be harmful especially in patients with respiratory conditions such as asthma or chronic obstructive pulmonary disease Beta-blockers reduce mortality in patients with hypertension, heart failure and coronary arterial disease. Traditionally they have not been given to patients with reversible airway disease (asthma or chronic obstructive pulmonary disease with a reversible obstructive component), for fear of adverse respiratory effects currently available cardioselective beta-blockers, celiprolol (celectol, RORER Laboratory) has ~2 agonist activity which could permit its use in asthmatic patients (6]. This study was carried out in order to evaluate the effects of a single dose of celiprolol on respiratory function in patients with moderate asthma. Thes Nonselective beta blockers should be used with caution, if at all, in smokers or people with asthma or other lung conditions. Cardioselective. A number of beta blockers, including atenolol (Tenormin) and metoprolol (Toprol, Lopressor), were designed to block only beta-1 receptors in heart cells

List of Cardioselective beta blockers - Drugs

  1. istration of 100 mg of atenolol was.
  2. The author writes that cardioselective beta-blockers with an affinity for the beta-1 receptor theoretically result in fewer adverse effects on the lungs because they competitively block the response to beta-adrenergic stimulation and selectively block beta-1 receptors with little or no effect on beta-2 receptors, except perhaps at high.
  3. Cardioselective beta blockers slow the heart rate and act to increase the ability of the blood to carry oxygen, which is useful in treating this disease. Cardioselective beta blockers are sometimes prescribed for the treatment of mitral valve prolapse. By lowering cardiac output and reducing the heart rate, beta blockers alleviate hypertension
  4. RESULTS: The cohort consisted of 35,502 people identified with active asthma and CVD, of which 14.1% and 1.2% were prescribed cardioselective and non-selective beta-blockers, respectively, during follow-up. Cardioselective beta-blocker use was not associated with a significantly increased risk of moderate or severe asthma exacerbations
  5. 4.4/5 (26 Views . 38 Votes) Bisoprolol or metoprolol succinate are usually prescribed as they are the most cardioselective beta-blockers, but there is evidence of benefit for a number of other beta-blockers and international guidelines do not specify which beta-blocker to prescribe. This is answered comprehensively here

Beta-Blockers and Asthma, How They Work, and Which One To Use

Beta-blockers use in patients with chronic obstructive

Do not prescribe beta-blockers to people with: A history of obstructive airways disease (such as asthma and chronic obstructive pulmonary disease) or bronchospasm. However, if there is no alternative, a cardioselective beta-blocker (such as bisoprolol and atenolol) can be used under specialist supervision Do not prescribe beta-blockers to people with: A history of asthma or bronchospasm. Reversible or severe chronic obstructive pulmonary disease (COPD). Beta-blockers can be used in people with COPD without significant reversible airways obstruction. Known intolerance or hypersensitivity to beta-blockers

In a meta-analysis of randomised controlled trials with cardioselective beta-blockers there was no significant change in FEV 1 compared with placebo, when given either as single −2.1% (95% CI −6.1-2.0%) or chronic dosing −2.6% (95% CI −5.9-0.8%), and also no significant effect on the FEV 1 response to beta-2-agonists Beta blockers are a group of drugs that inhibit the sympathetic activation of β-adrenergic receptors. Cardioselective blockers (e.g., atenolol, bisoprolol) primarily block β1 receptors in the heart, causing decreased heart rate, cardiac contractility, cardiac workload, and AVN conduction CONCLUSIONS: Cardioselective beta-blockers do not produce clinically significant adverse respiratory effects in patients with mild to moderate reactive airway disease. The results were similar for patients with concomitant chronic airways obstruction. Given their demonstrated benefit in such conditions as heart failure, cardiac arrhythmias, and.

Safe Beta Blockers in Patients with Reactive Airway Diseas

Beta blockers are traditionally recommended to treat conditions such as abnormal heart rhythm and chest pain. Beta blockers may cause upset stomach. Contraindications for beta blockers may include asthma. Hypoglycemia may be signaled by symptoms such as chills. The presence of bradycardia may lead to an extremely low heart rate and dizziness Non-cardioselective beta blockers, like propranolol or nadolol, helps minimize arrhythmias, blood pressure, heart rate, and the workload on the heart. Cardioselective beta blockers, like atenolol and esmolol, avoid the latter problem by targeting and affecting just the beta-1 (heart) receptors Beta-blockers, including those considered to be cardioselective, should usually be avoided in patients with a history of asthma, bronchospasm or a history of obstructive airways disease. However, when there is no alternative, a cardioselective beta-blocker can be given to these patients with caution and under specialist supervision

Beta-blockers in patients with asthma and COP

Cardioselective beta-blockers include atenolol, metoprolol, bisoprolol and acebutolol. A recent Cochrane analysis documented the safety of cardioselective beta-blockers in COPD. Indeed, single doses of cardioselective beta-blockers as well as treatment of longer duration ranging from 2 days to 12 weeks led to a non-significant worsening in lung. cardioselective beta-blockers include atenolol, bisoprolol and metoprolol. Partial agonist activity (intrinsic sympathomimetic activity) : This manifests as a beta- Asthma is an absolute contraindication for all beta-blockers. Bradycardia and impairment of myocardial contractility There are multiple case reports in the medical literature where non-selective beta-blockers led to exacerbations of bronchospasm in patients with asthma. As recently as 1995, one could find admonishments like this in the medical literature: Worsening or precipitation of asthma by beta-adrenoceptor antagonists is well recognized

In fact, older guidelines listed asthma as an absolute contraindication to administration of non-cardio-selective beta blockers including eye drops used in glaucoma treatment.(3) However, currently there are several cardioselective agents such as atenolol, bisoprolol, and metoprolol that are at least 20 times more potent at blocking beta-1. Beta-blockers were cardioselective in 88% of cases, and their administration resulted in a reduction of 22% in all-cause mortality when added to established inhaled stepwise therapy, regardless of COPD severity. Furthermore, patients treated with beta-blockers reduced oral corticosteroid use and hospital admissions due to respiratory disease Cardioselective and noncardioselective beta-blockers were similar in this regard (HR, 0.60; 95% CI, 0.48-0.76; p 0.0001, and HR, 0.74; 95% CI, 0.60-0.90; p = 0.003, respectively). Subgroup analyses in patients with heart failure and myocardial infarction demonstrated similarly favorable effects of beta-blockers on all-cause mortality

Cardioselective beta-blockers block hormonal stimulation of the heart which helps reduce systolic pressure, heart rate, the force of muscle contraction, as well as improving oxygenation and increasing exercise tolerance. 3 Non-cardioselective agents decrease the activity of the heart. They block receptors in the heart that help to reduce systolic pressure, heart rate, and the force of. Beta blockers generally aren't used in people with asthma because of concerns that the medication may trigger severe asthma attacks. In people who have diabetes, beta blockers may block signs of low blood sugar, such as rapid heartbeat. It's important to check your blood sugar regularly if you have diabetes and you're taking a beta blocker Mechanism of Action. Blocks beta-receptors of the sympathetic nervous system. Some agents act primarily on beta receptors in the heart. these are called cardioselective. Beta- blockage results in decreased heart rate, blood pressure, and contractility of the heart. thereby reducing the demand for oxygen by the heart

In the acute setting, the use of cardioselective beta-blockers (i.e., beta-1 > beta-2 antagonism) is preferred when indicated for patients with asthma. [13] Noninvasive airway management, such as placement of a supraglottic airway (SGA), is associated with a decreased risk of postoperative hypoxemia and coughing compared to the use of an. Despite clear evidence of the effectiveness of β-blockers in the management of patients with cardiac disease (heart failure and coronary artery disease) or arterial hypertension, use of these agents has traditionally been contraindicated in chronic obstructive pulmonary disease (COPD) mainly because of anecdotal evidence and case reports citing acute bronchospasm after their administration () TOPICS: Primary hypertension, essential hypertension, thiazide, ace inhibitors, angiotensin receptor blockers, calcium channel blockers, asthma, cough. All beta blockers are contra-indicated in severe or unstable asthma. Non-cardioselective beta blockers are always contra-indicated in asthma, even mild asthma. Patients with asthma who require a beta blocker for the treatment of hypertension only: nebivolol. Diabetic patients who require a beta blocker: atenolol, bisoprolol, metoprolol Thus, non-cardioselective beta blockers have an effect on the bronchi, inducing bronchoconstriction. As a result, they are contraindicated in asthma patients who need bronchodilation in order to to be able to go through an attack. This pharmaceutical class includes molecules such as: propranolol, atenolol, bisoprolol, etc

UpToDat

{{configCtrl2.info.metaDescription}} This site uses cookies. By continuing to browse this site you are agreeing to our use of cookies Cardioselective beta blockers can sometimes be used in well-regulated asthma and COPB. Raynaud's disease Raynaud's disease is a disorder where some body part such as fingers and toes suffer reduced blood flow, caused by narrowing of smaller arteries that are supplying them Beta-blockers are a type of medication that's traditionally used to treat heart conditions. Sometimes, beta-blockers are prescribed for off-label use to help manage anxiety symptoms. We'll go over. Beta-blockers can precipitate asthma and should usually be avoided in children with a history of asthma or bronchospasm. If there is no alternative, a child with well-controlled asthma can be treated for a co-existing condition (e.g. arrhythmia) with a cardioselective beta-blocker, which should be initiated with caution at a low dose by a. Salpeter S, Ormiston T, Salpeter E: Cardioselective beta-blockers for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2005;CD003566. 81. Salpeter SR, Ormiston TM, Salpeter EE. Cardioselective beta-blockers in patients with reactive airway disease: a meta-analysis. Ann Intern Med. 2002;137:715-25

Therefore, patients with asthma should not normally be treated with beta-blockers. However, under certain circumstances, eg, as prophylaxis after myocardial infarction, there may be no acceptable alternatives to the use of beta-adrenergic-blocking agents in patients with asthma. In this setting, consider cardioselective beta-blockers, although. Beta-1 receptors blocker - Cardioselective/selective β 1 /II generation beta blockers: Preferred in diabetes mellitus , bronchial asthma, peripheral vascular disease & hyperlipidemia. Nebivolol Find patient medical information for Metaprel Asthma Mist Inhalation on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings

Asthma and beta blockers drug dilemma: - GP Updat

Beta-blockers are drugs that can help slow heart rate, prevent migraine episodes, manage glaucoma, and more. Learn more about the uses of beta-blockers here Drugs that mainly target beta-1 receptors are called cardioselective beta blockers while non-cardioselective beta blockers bind to both receptor types. cardioselective beta blockers include metoprolol and atenolol, acebutolol, bisoprolol, esmolol. Is this the reason that if a person has significant asthma or copd that selective blockers are Cardioselective beta-blockers More recent beta-blockers were designed to target only beta-1 receptors in the heart cells. They don't affect other beta-2 receptors and are therefore safer for.

What Are Beta-Blockers and What Do They Do?

Cardio protective drugs: Beta-blocker

Beta-blockers have central nervous system (CNS) adverse effects (sleep disturbances, fatigue, lethargy) and exacerbate depression. Nadolol affects the CNS the least and may be best when CNS effects must be avoided. Beta-blockers are contraindicated in patients with 2nd- or 3rd-degree atrioventricular block, asthma, or sinus node dysfunction Introduction. The presence of cardiovascular disease and chronic obstructive pulmonary disease (COPD) are intertwined because of the risk of smoking induced atherosclerosis in patients with COPD.1 Despite the proved benefits of β blockers in treating hypertension, ischaemic heart disease, and heart failure, many doctors are reluctant to prescribe β blockers for patients with concurrent COPD. Thus, Nonselective Beta Blockers, especially, should be used with caution in patients with respiratory disorders, such as Asthma, COPD, and Emphysema. Selective Beta Blockers (also called cardioselective) have a greater affinity for blocking specific adrenoceptors, more discriminately, in this case, those located in myocardial (heart) tissue. Beta‐blockers in patients with asthma and COPD Beta‐blockers in patients with asthma and COPD Spencer, Rachel; Serumaga, Brian 2012-02-19 00:00:00 In this series we present a number of prescribing safety indicators developed as part of an RCGP project.1 The evidence base behind each of the indicators is given along with information to illustrate their clinical significance

The cardioselective beta-blockers act upon beta-1 receptors much more than the beta-2 receptors. For this reason, the cardioselective beta-blockers are safer to use in patients with asthma. Cardioselective beta blockers are useful in the acute treatment of MI and other acute coronary syndromes (ACS) Carvedilol is a nonselective beta blocker and alpha 1 blocker that is useful in the management of chronic heart failure (in addition to cardioselective beta blockers

Beta-blockers for cardiovascular conditions: one size does

Observational studies have included a more varied breadth of specific beta-blockers, however they do not present a clear picture: the population-based Rotterdam Study reported significant decreases in FEV1 associated with both cardio and non-cardioselective beta-blockers, while two other studies, one from Scotland and an one from Japan reported. Summary. Recent trials have shown the unequivocal benefits of beta blockers in patients with chronic systolic heart failure. These benefits include improved survival (30-35%) and a reduced need for hospitalisation. However, beta blockers may also make a patient with heart failure worse, especially when treatment begins

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Noncardioselective Beta-Blocker Use in Patients With

Asthma is a long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. Symptoms include episodes of wheezing, coughing, chest tightness, and shortness of breath. These may occur a few times a day or a few times per week. Depending on the person, asthma symptoms may. However, under certain circumstances, e.g., as prophylaxis after myocardial infarction, there may be no acceptable alternatives to the use of beta-adrenergic-blocking agents in patients with asthma. In this setting, consider cardioselective beta-blockers, although they should be administered with caution

Say What, Beta-Blockers for Asthma? American Journal of

If a patient with diabetes or pulmonary disorders needs to take beta blockers, the cardioselective beta blockers are preferred, such as metoprolol (lopressor) and atenolol. Cardioselective just means that they have more effect on beta-1 receptors and cause less bronchospasm and impairment of glucose metabolism The non-cardioselective beta blockers market is segmented on the basis of indication, target, drugs, route of administration, end-users and distribution channel. On the basis of indication, the non-cardioselective beta blockers market segmented into angina, hypertension, heart failure, arrhythmias and other

Adrenergic Blocking Drugs

Cardioselective beta-blockers for reversible airway

Cardioselective beta-blockers worsen asthma. False. Cardioselective beta-blockers target primarily beta-1 receptors, which are found in the heart. Beta-2 receptors are found in the lungs. Which non-selective beta blocker is used to treat/relieve glaucoma? Timolol Nonselective beta-blockers are the earliest developed beta-blockers. They affect both beta 1 and beta 2 receptors, so they can affect cardiac (heart) and pulmonary (lung) actions. This type of beta-blocker is usually not appropriate for patients with lung conditions like asthma Beta-2 Agonists/Non-Cardioselective Beta-Blockers Interactions . This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or. Non-cardioselective beta blockers market is expected to gain market growth in the forecast period of 2020 to 2027. Data Bridge Market Research analyses the market is growing with the healthy CAGR. Side effects of beta blockers can include fatigue, dizziness, cold hands and feet, exercise intolerance, insomnia, shortness of breath, depression, and impotence. Some beta blockers can worsen asthma or other chronic lung disorders by narrowing the airways inside the lungs. They also may cause dangerously slow heart rates in unusual circumstances

Beta blockers - AMBOS

Beta Blockers 05/20/2020 ° The next two weeks will be discussing medications used in the treatment of cardiovascular disease. Hypertension coronary, angina, heart failure and arrhythmias. ° ° We will also discuss medications used in the treatment of hyperlipidemia as elevated cholesterol levels constitute a major risk factor in the development of coronary heart disease Most beta blockers produce these CNS & sexual side effects to some extent. With regards to how beta-blockers cause insomnia, it has been observed that beta-1 blockers decrease the release of melatonin, a compound involved in sleep & circadian rhythm. To put this in context, ramelteon (Rozerum ®) is a melatonin agonist used to treat insomnia

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